---

1️⃣ Introduction to Vitamin K2

Vitamin K2 is a fat-soluble vitamin that plays a key role in bone mineralization, heart health, and blood clotting regulation. It helps direct calcium to bones and teeth while preventing arterial calcification, making it essential for long-term skeletal and cardiovascular health.

At Chibio Biotech, we offer both MK-4 (Menatetrenone) and MK-7 (Menaquinone-7) forms of Vitamin K2, with various concentrations for different applications​​​​​.

---

2️⃣ Types of Vitamin K2 Powder from Chibio Biotech

✔ Vitamin K2 (MK-4)

• ✅ 98% Pure MK-4 (Synthesis) – Highly potent, used in pharmaceuticals & dietary supplements.
• ✅ 1.0% MK-4 in β-Cyclodextrins (β-CD) (Synthesis) – Enhanced water solubility, ideal for food fortification & beverages.

✔ Vitamin K2 (MK-7)

• ✅ 0.1% (1,000 ppm) Natural MK-7 – Fermented from Bacillus subtilis natto, ideal for functional foods & supplements.
• ✅ 1% (10,000 ppm) Natural MK-7 – Higher potency, perfect for premium supplements & pharmaceuticals.
• ✅ 2% (20,000 ppm) Natural MK-7 – Ultra-high strength for specialized medical & nutraceutical applications.

MK-4 is synthetic, while MK-7 is naturally sourced from natto fermentation, ensuring high bioavailability & stability​​​​​.

---

3️⃣ CAS Number & Chemical Information

• Vitamin K2 (MK-4) (Menatetrenone): CAS 863-61-6
• Vitamin K2 (MK-7) (Menaquinone-7): CAS 2124-57-4
• Molecular Formula: C₃₁H₄₀O₂

MK-4 is shorter-acting, while MK-7 provides long-lasting bioavailability in the body.

---

4️⃣ Specifications & Solubility

Type	Appearance	Solubility	Assay	Loss on Drying
MK-4 98% (Synthesis)	Yellow powder	Soluble in ethanol, slightly in methanol, insoluble in water	≥98%	≤0.5%
MK-4 1.0% in β-CD (Synthesis)	Yellow powder	Water-dispersible	≥1.0%	≤7.0%
MK-7 0.1% (Natural)	Light yellow powder	Water-dispersible	≥1,000 ppm	≤5.0%
MK-7 1% (Natural)	Light yellow powder	Water-dispersible	≥10,000 ppm	≤5.0%
MK-7 2% (Natural)	Light yellow powder	Water-dispersible	≥20,000 ppm	≤5.0%

All grades meet USP, EP, and food safety standards​​​​​.

---

5️⃣ Benefits & Functions of Vitamin K2

✨ Bone & Teeth Health

• Activates osteocalcin, helping bind calcium to bones.
• Reduces the risk of osteoporosis and fractures.

✨ Cardiovascular Protection

• Prevents arterial calcification, supporting healthy blood vessels.
• Reduces the risk of atherosclerosis & heart disease.

✨ Blood Clotting Regulation

• Essential for coagulation & wound healing.
• Works synergistically with Vitamin D & Calcium.

✨ Brain & Metabolic Health

• May support cognitive function & nerve protection.
• Helps regulate insulin sensitivity & metabolic health.

---

6️⃣ Applications of Vitamin K2 Powder

✅ Dietary Supplements – Capsules, tablets, soft gels, and gummies.
✅ Functional Foods & Beverages – Fortified dairy, plant-based products, juices.
✅ Pharmaceuticals – Used in medical treatments for osteoporosis & cardiovascular diseases.
✅ Animal Nutrition – Supports bone development & immune function in livestock.
✅ Cosmetics & Skincare – Emerging use in anti-aging & skin elasticity formulations.

---

7️⃣ MK-4 vs. MK-7: Which One to Choose?

Feature	MK-4 (Menatetrenone)	MK-7 (Menaquinone-7)
Source	Synthetic	Natural (Natto Fermentation)
Bioavailability	Short half-life	Long-lasting effect
Best For	High-dose therapeutic use	Daily supplementation
Calcium Transport	Supports bone health	Superior for cardiovascular & bone support
Absorption	Requires higher doses	More effective at lower doses

💡 Recommendation: If you need short-term, high-dose supplementation, use MK-4. If you need long-term cardiovascular & bone benefits, use MK-7​​​​​.

Vitamin K2 contributes to bone and cardiovascular health. Therefore, two vitamin K2 homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular health.

Difference Between  MK-4 & MK-7
Vitamin K2 Type	MK-4 (MENAQUINONE-4)	MK-7 (MENAQUINONE-7)
CAS No.	863-61-6	2124-57-4
Molecular Formula	C31H40O2	C46H64O2
Molecular Weight	444.66	649.00
Main Source	Meat	Natto
Absorption & Transfer	Rapidly removed from the liver by the same lipoprotein as a carrier	Redistributed primarily in the liver by low-density lipoproteins
Bioavailability	Studies have shown that the side chain of vitamin K2 (MK-7) is longer than vitamin K2 (MK-4), for which it can be stored in the human body for a long time, and its bioavailability in extrahepatic tissues is higher
Effective Use Level	mg/d (mg), three times a day, 15 mg each time (equivalent to 45,000 micrograms per day), and is required to be taken 500 times more than vitamin K2 (MK-7)	μg/d grade (microgram level), once a day, 90 micrograms each time
Production Process	Obtained by chemical synthesis	Naturally extracted or chemically synthesized
Functional Use	Osteoporosis	Osteoporosis, Improved arterial Calcification, Treatment of Parkinson’s disease

 

MK-4 present in food does not contribute to the vitamin K status as measured by serum vitamin K levels. MK-7, however significantly increases serum MK-7 levels and therefore may be of particular importance for extrahepatic tissues.

Therefore, It can be seen that vitamin K2 (MK-7) far exceeds vitamin K2 (MK-4) in terms of biological activity, bioavailability and efficacy.

---

8️⃣ Why Choose Chibio Biotech?

• 🏆 8+ Years of Experience in Vitamin & Natural Ingredients.
• ✅ Certified Quality – Meets USP, EP, Food-Grade Standards.
• 🌱 Natural & Synthetic Options – Suitable for different applications.
• 📦 Flexible Supply & OEM Customization – Bulk supply & private labeling available.

---

9️⃣ Why Your Business Needs Vitamin K2?

🔹 Rising Market Demand – Used in nutraceuticals, pharmaceuticals, and functional foods.
🔹 Proven Health Benefits – Essential for bone density & heart health.
🔹 Versatile & Cost-Effective – Available in multiple grades for different needs.
🔹 Stable & Long Shelf Life – Ensures high potency & easy storage.

---

🔟 Call-to-Action: Get Premium Vitamin K2 Powder Today! 🚀

Looking for high-quality Vitamin K2 MK-4 & MK-7 for food, supplements, or pharmaceuticals?

📩 Email: sales@chibiotech.com
📞 Phone: +86 (0)532 66983270
🌍 Website: www.chibiotech.com

✅ Boost your formulations with Chibio Biotech’s premium Vitamin K2! 🌿✨