Injection Grade Hyaluronic Acid / Sodium Hyaluronate (1.2 – 1.6M Da) – High-Purity HA for Medical & Aesthetic Applications

GMP-Certified, Ultra-Pure Hyaluronic Acid for Injections – Trusted for Medical & Aesthetic Use

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1. What is Injection Grade Sodium Hyaluronate?

Injection Grade Sodium Hyaluronate is a high-purity, medical-grade form of Hyaluronic Acid (HA), specially designed for injectable applications in orthopedics, dermatology, and ophthalmology.

With a molecular weight of 1.2 – 1.6M Da, it offers superior viscoelasticity, water retention, and biocompatibility, making it an ideal ingredient for dermal fillers, joint injections, and ophthalmic viscoelastic solutions.

At Chibio Biotech, our GMP-certified Injection Grade HA is manufactured with ultra-low endotoxin levels, ensuring maximum safety and efficacy for medical and aesthetic treatments.

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2. Molecular Weight & Key Benefits

Molecular Weight	Range (Da)	Key Benefits	Best Application
Injection Grade HA	1.2 – 1.6M Da	High viscoelasticity, long-lasting hydration, excellent biocompatibility	Joint injections, dermal fillers, ophthalmic surgery

🔹 Why 1.2 – 1.6M Da?

• Provides optimal viscosity and stability for intra-articular injections (joint therapy).
• Forms a strong hydration network, making it ideal for dermal fillers and skin rejuvenation.
• Ensures smooth injectability for ophthalmic surgeries, reducing friction and protecting eye tissues.

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3. Technical Specifications

Feature	Specification
Product Name	Sodium Hyaluronate (Injection Grade)
Chemical Formula	(C₁₄H₂₀NNaO₁₁)n
CAS Number	9067-32-7
Appearance	White or almost white, highly hygroscopic powder
Purity	≥ 95%
Solubility	Fully soluble in water, creating a clear and viscous solution
pH	5.4-8.2
Intrinsic Viscosity	2.0 – 2.6 M3/KG
Endotoxin Level	≤ 0.005 IU/mg
Microbial Limits	≤ 100 CFU/g
Heavy Metals	≤ 10 ppm
GMP Certification	✅ Yes

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Solubility:

Injection Grade Hyaluronic Acid (also known as Sodium Hyaluronate for injectable use) typically has the following solubility characteristics:

Solubility of Injection Grade Hyaluronic Acid:

1. Water Solubility:

   • Highly soluble in water, forming a clear, viscous solution. This makes it ideal for use in injectable formulations, as it needs to dissolve completely to ensure safe and effective administration.
   • The molecular weight of Injection Grade HA typically ranges from 1.2M Da to 1.5M Da, which provides the necessary viscosity and biocompatibility for joint injections, dermal fillers, and ophthalmic applications.

2. Oil Solubility:

   • Not soluble in oils, as hyaluronic acid is a hydrophilic substance. Therefore, it is not typically used in oil-based formulations for injectable purposes.

3. Formulation Context:

   • Injection Grade HA is formulated in sterile, aqueous solutions with low endotoxin levels, ensuring its safety and efficacy for medical applications like joint therapy (for osteoarthritis), dermal fillers, and eye treatments.

Overall, Injection Grade Hyaluronic Acid is designed to dissolve in water and is suitable for aqueous-based injections, ensuring proper tissue integration and hydration without irritation.

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4. Key Benefits of Injection Grade Sodium Hyaluronate

✅ Superior Biocompatibility – Naturally present in the human body, reducing risk of allergic reactions.
✅ Enhanced Viscoelasticity – Provides cushioning and lubrication in joint injections and dermal fillers.
✅ Long-Lasting Hydration – Binds water molecules to maintain moisture and skin plumpness.
✅ Ultra-Low Endotoxin Levels – Ensures high safety for medical and injectable use.
✅ Smooth Injectability – Optimized molecular weight ensures easy administration and even distribution.
✅ GMP Certified & Pharmaceutical-Grade – Meets strict global medical standards.

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5. Applications of Injection Grade Sodium Hyaluronate

A. Orthopedic & Joint Therapy

🔹 Intra-Articular Joint Injections – Used for osteoarthritis treatment, reducing pain and improving joint mobility.
🔹 Synovial Fluid Supplementation – Restores joint lubrication and cushioning.

B. Aesthetic & Dermatology Applications

🔹 Dermal Fillers & Injectable HA – Provides volume, wrinkle reduction, and skin hydration.
🔹 Anti-Aging Treatments – Used in mesotherapy and skin boosters to improve elasticity and hydration.

C. Ophthalmic & Surgical Applications

🔹 Ophthalmic Viscoelastic Solutions (OVD) – Protects eye tissues during cataract and LASIK surgery.
🔹 Corneal Protection & Healing – Assists in wound healing after eye surgeries.

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6. GMP-Certified Manufacturing Process

1️⃣ Fermentation-Based Production

• Non-animal origin, produced via bacterial fermentation to ensure purity.

2️⃣ Ultra-Purification & Endotoxin Removal

• Advanced filtration ensures ultra-low endotoxin levels (≤ 0.05 EU/mg).

3️⃣ Molecular Weight Optimization

• Adjusted to 1.2 – 1.6M Da for optimal injectability and bioactivity.

4️⃣ Sterilization & Quality Testing

• GMP-certified processing, ensuring pharmaceutical-grade sterility.

5️⃣ Final Packaging & Distribution

• Sealed in pharmaceutical-grade packaging to maintain stability and sterility.

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7. Why Choose Chibio Biotech for Injection Grade Sodium Hyaluronate?

🌍 GMP-Certified & Ultra-Pure – Meets global medical standards for injectables.
🔬 Ultra-Low Endotoxin Levels – Ensures maximum safety and biocompatibility.
📦 Custom Molecular Weight – Optimized 1.2 – 1.6M Da for injections.
🌱 Non-Animal Origin & High Purity – Produced through advanced fermentation technology.
📈 Large-Scale Production & Reliable Supply – Consistent and stable bulk manufacturing.

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8. Packaging & Storage

📦 Packaging: Customized pharmaceutical-grade sterile packaging
🌡 Storage: Store in a cool, dry place (2-10°C)
⏳ Shelf Life: Two years (Unopened packaging)

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9. Get in Touch – Inquiry Now!

Looking for high-quality Injection Grade Sodium Hyaluronate for medical and aesthetic applications?

📩 Email: sales@chibiotech.com
📞 Phone: +86 (0)532 66983270
🌍 Website: www.chibiotech.com

✅ The Future of Injectable HA Starts with Chibio Biotech! 🚀

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Please view more details about the following all grades of hyaluronic acid we can provide for various applications:

Cosmetic, Food Grade Hyaluronic Acid

Cationic Hyaluronic Acid

Sodium Acetylated Hyaluronate

Oil-Dispersion Hyaluronic Acid

Tremella Sourced Hyaluronic Acid

Eye-Drop Grade Hyaluronic Acid

Injection Grade Hyaluronic Acid