Hyaluronic Acid (Food, Cosmetic Grade)

Hyaluronic Acid (Food, Cosmetic Grade)

Additional information

Product Name

Hyaluronic Acid/Sodium Hyaluronate
(Food, Cosmetic Grade)

Appearance

White or almost white hygroscopic powder or fibrous aggregate

Chemical Name

Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4])

Molecular Formula

(C₁₄H₂₀NNaO₁₁)n

Cas No.#

9067-32-7

INCI Name

Sodium Hyaluronate

Main Functions

Superior Hydration, Anti-Aging Properties, Joint & Cartilage Support, Fast Absorption, Safe & Biocompatible

Main Applications

Used in cosmetics, food supplements, pharmaceuticals, and medical formulations.

Product Details

Hyaluronic Acid (Sodium Hyaluronate) – The Ultimate Natural Hydrating Ingredient

Unlock the power of Hyaluronic Acid for skin, health, and wellness with Chibio Biotech’s premium-grade solutions!


What is Hyaluronic Acid (Sodium Hyaluronate)?

Hyaluronic Acid (HA), also known as Sodium Hyaluronate, is a natural polysaccharide that is widely found in human skin, joints, eyes, and connective tissues. It is a powerful humectant that can hold up to 1,000 times its weight in water, making it an essential ingredient in cosmetics, food supplements, and pharmaceuticals.

At Chibio Biotech, we provide high-purity Hyaluronic Acid in cosmetic and food-grade forms, with a molecular weight range of 0.8 kDa to 2M Da, tailored for different applications.

Sodium Hyaluronate is the sodium salt of Hyaluronic Acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. It exists naturally in humans and animals, and is found in high concentrations in intercellular substance, eye vitreous, umbilical cord, skin, Synovial fluid and rooster/cock comb, and many other soft connective tissues.

Our Hyaluronic Acid source is from non-animal materials: Tremella, Streptococcus zooepidemicus. 

The bacteria used for the fermentation is non-GMO and non-hemolytic. Fermentation takes place in a plant-based growth medium without any animal products or byproducts. Sustainable, 100% Vegan and Vegetarian.


Grades & Molecular Weight Classification

1. Cosmetic Grade Hyaluronic Acid

  • Used in skin care, personal care, and beauty products.
  • Improves skin hydration, elasticity, and anti-aging properties.

2. Food-Grade Hyaluronic Acid

  • Used in functional foods, dietary supplements, and beverages.
  • Supports joint health, eye lubrication, and overall skin wellness.

Hyaluronic Acid Molecular Weight Ranges & Their Benefits

Molecular Weight Range (Da) Best for Key Benefits
Ultra-Low MW 0.8 – 1k Da Cosmetic, Food Deep skin penetration, anti-aging, fast absorption
Low MW 1k – 1.5k Da Cosmetic, Food Improves hydration, reduces fine lines, enhances absorption
Oligo HA 3 – 6k Da Cosmetic, Food Lightweight, increases elasticity, repairs skin barrier
Small MW 8 – 15k Da Cosmetic, Food Hydration, wrinkle reduction, promotes skin regeneration
Medium MW 20 – 30k Da Cosmetic, Food Retains moisture, anti-wrinkle, enhances absorption
Regular MW 30 – 50k Da Cosmetic, Food Hydration, firming, skin elasticity improvement
High MW 50 – 100k Da Cosmetic, Food Surface moisture retention, long-lasting hydration
Very High MW 100 – 500k Da Cosmetic, Food Film-forming, enhances skin texture and elasticity
Super High MW 800k – 1,000k Da Cosmetic, Food Lubrication, long-lasting moisture protection
*Pharmaceutical MW 1.0M – 1.5M Da (Typical 1.2M Da) Cosmetic, Food Anti-aging, long-term hydration, tissue repair
Ultra-High MW 1.5M – 1.8M Da Cosmetic, Food Skin barrier protection, film-forming effect
Extreme MW 1.8M – 2.0M Da Cosmetic, Food Joint lubrication, moisture retention, medical applications

Key Benefits Based on Molecular Weight

  • High Molecular Weight (HMW): Forms a dense protective film, long-lasting moisture retention, strong anti-aging effect.
  • Medium Molecular Weight (MMW): Enhances skin hydration, provides lubrication, stabilizes emulsions.
  • Low Molecular Weight (LMW): Deep skin penetration, enhances skin nutrition, improves elasticity.
  • Oligo Hyaluronic Acid: High absorption, anti-aging, promotes skin recovery after sunburn.

* The term “Pharmaceutical MW” was used instead of “High MW” or other descriptions because Hyaluronic Acid (HA) in the 1.0M – 1.5M Da range (typically 1.2M Da) is commonly used in pharmaceutical and medical applications, such as:

  • Injectable fillers (dermal fillers for anti-aging)
  • Ophthalmic solutions (eye drops for dry eyes)
  • Wound healing products (medical-grade HA for tissue regeneration)
  • Joint injections (used in osteoarthritis treatments for lubrication and shock absorption)

This molecular weight is ideal for pharmaceutical applications due to its high viscosity, strong water retention, and excellent bioactivity, making it distinct from other molecular weight categories primarily used in cosmetics and food.


Technical Specifications:

Basic Information

  • Product Name: Sodium Hyaluronate (Hyaluronic Acid)
  • Chemical Name: Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4])
  • INCI Name: Sodium Hyaluronate
  • Molecular Formula: (C₁₄H₂₀NNaO₁₁)n
  • CAS Number: 9067-32-7
  • HS Code: 3913900090
  • Appearance: White or almost white hygroscopic powder or fibrous aggregate

Purity & Composition

Component Specification
Sodium Hyaluronate ≥ 95%
Solubility Sparingly soluble or soluble in water, practically insoluble in acetone and ethanol
Molecular Weight 800 – 2,000,000 Da
Intrinsic Viscosity 0.19 – 40.6 dL/g
pH 5.0 – 8.5
Protein Content ≤ 0.1%
Loss on Drying ≤ 10.0%
Chlorides ≤ 0.5%
Iron (Fe) ≤ 80 ppm
Total Aerobic Microbial Count (TAMC) ≤ 100 CFU/g
Staphylococcus aureus Negative/g
Pseudomonas aeruginosa Negative/g

Packaging & Storage

📦 Packaging: Customized according to customer requirements
🌡 Storage: Store in a cool and dry place (2-10°C)
Shelf Life: Two years (Unopened packaging)


Key Benefits of Hyaluronic Acid

Superior Hydration – Retains water, keeping skin plump and youthful.
Anti-Aging Properties – Reduces wrinkles and improves skin elasticity.
Joint & Cartilage Support – Enhances lubrication and reduces inflammation.
Fast Absorption – Different molecular weights allow deep penetration.
Safe & Biocompatible – Naturally occurring in the body, non-toxic, and gentle.
Versatile Applications – Used in cosmetics, food supplements, pharmaceuticals, and medical formulations.


Applications of Hyaluronic Acid

Its water solution has a very high moisture retention, viscoelasticity and lubricity. It can be widely used in cosmetics, pharmaceuticals, health food and other industries.

1. Cosmetics & Personal Care

  • Moisturizing creams, serums, and lotions – Deep hydration and anti-aging.
  • Face masks and gels – Skin plumping and hydration boost.
  • Lip care & hair care – Retains moisture, preventing dryness.

2. Food & Dietary Supplements

  • Joint health supplements – Supports cartilage and joint lubrication.
  • Functional beverages & gummies – Provides hydration from within.
  • Beauty-from-within products – Enhances skin elasticity and radiance.

3. Pharmaceutical & Medical Applications

  • Eye drops – Used as an artificial tear component for dry eyes.
  • Wound healing & tissue regeneration – Promotes skin repair and recovery.
  • Injections & fillers – Used in dermal fillers for anti-aging treatments.

Manufacturing Flowchart of Sodium Hyaluronate (Hyaluronic Acid)

Step-by-Step Production Process

1️⃣ Bacterial Fermentation Process

  • Test Tube Slant Culture (12h) → Initial bacterial cultivation
  • Shake Flask Culture (12h) → Early-stage microbial expansion
  • Seeding Tank Culture (10h, 37°C) → Microbial propagation
  • Fed-Batch Fermentation Tank → Large-scale HA fermentation
  • Mechanical Agitating Fermentation Tank (37°C) → Controlled growth environment

2️⃣ Fermentation & Purification

  • Fermentation Fluid Collection → Extraction of HA-rich broth
  • First Alcohol Precipitation → Removes unwanted components
  • Crude Hyaluronic Acid Collection → Initial HA extraction

3️⃣ Filtration & Purification

  • Dissolution in Demineralized Water (60°C) → Ensures purity
  • pH Adjustment → Optimizes HA stability
  • Coarse Filtration → Removes large impurities
  • Fine Filtration (0.22 μm membrane filter) → Achieves ultra-purity
  • Second Alcohol Precipitation → Further purification
  • Dehydration & Centrifugation (1h) → Removes excess moisture

4️⃣ Final Processing & Packaging

  • Rotary Vacuum Drying (60°C) → Produces HA in powder form
  • Quality Testing → Ensures compliance with industry standards
  • Packaging & Storage → Ready for shipment and application

Why Choose Chibio Biotech for Hyaluronic Acid?

🌱 Premium Quality – High-purity HA with strict quality control.
🌎 Global CertificationsISO22000, Kosher, Halal, FDA Certified.
🔬 Strong R&D Expertise – Continuous innovation in molecular weight HA production.
📦 Reliable Supply Chain – Large-scale production with guaranteed consistency.
💡 Custom Solutions – Tailored molecular weight ranges based on industry needs.


Get in Touch – Inquiry Now!

Looking for high-quality Hyaluronic Acid (Sodium Hyaluronate) for cosmetics, food supplements, or pharmaceuticals?
Contact Chibio Biotech today for bulk orders and customized solutions!

📩 Email: sales@chibiotech.com
📞 Phone: +86 (0)532 66983270
🌍 Website: www.chibiotech.com

Boost hydration & wellness naturally with Hyaluronic Acid – The Future of Beauty & Health! 🚀


Please view more details about the following all grades of hyaluronic acid we can provide for various applications:

Cosmetic, Food Grade Hyaluronic Acid

Cationic Hyaluronic Acid

Sodium Acetylated Hyaluronate

Oil-Dispersion Hyaluronic Acid

Tremella Sourced Hyaluronic Acid

Eye-Drop Grade Hyaluronic Acid

Injection Grade Hyaluronic Acid

Get in touch with us to boost your business

Headquarter

Block B, Vanke Center, No.2 Heilongjiang South Road, Shibei District, Qingdao City, China 266033

Phone

+86 (0)532 66983270

Cellphone / WhatsApp / WeChat

+86 156 6577 2296
+86 133 8100 5417

sales@chibiotech.com

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