Aspergillus Niger Chitosan Oligosaccharide – High-Quality Fungal-Derived Oligosaccharide

What is Aspergillus Niger Chitosan Oligosaccharide?
Aspergillus Niger Chitosan Oligosaccharide is a low-molecular-weight derivative of chitosan, extracted from the fungal species Aspergillus niger, specifically designed with a molecular weight of ≤ 5kDa.

Known for its excellent solubility and bioactivity, this oligosaccharide is composed of shorter chains of D-glucosamine units, which makes it more easily absorbed and highly effective in various applications.

It is particularly valued in the pharmaceutical, dietary supplement, and cosmetic industries for its enhanced functionality and safety profile.

Chitosan Oligosaccharide is a low molecular weight derivative of chitosan, which consists of a series of D-glucosamine units linked by β-(1→4) glycosidic bonds. It retains the beneficial properties of chitosan, such as biodegradability, biocompatibility, and antimicrobial activity, but with enhanced solubility and absorption due to its shorter polymer chains.

CAS Number:

• CAS No.: 148411-57-8

Chemical Structure:

• Chemical Formula: (C6H11NO4)n(C_6H_{11}NO_4)_n(C6​H11​NO4​)n​
• The chemical structure of Aspergillus Niger Chitosan Oligosaccharide consists of D-glucosamine units linked by β-(1→4) glycosidic bonds, similar to chitosan, but with significantly shorter chains. This structure allows for greater solubility and faster absorption in biological systems.

The repeating unit is represented as:

• [–(C_8H_{15}NO_5)–]n

Where “n” represents the degree of polymerization, which is lower in oligosaccharides, typically ≤ 5kDa.

Specification

• Molecular Weight: ≤ 5kDa
• Appearance: Light yellow powder
• Degree of Deacetylation: ≥ 98%
• Solubility: Easily soluble in water  solutions
• Moisture Content: ≤ 10%

Solubility

Aspergillus Niger Chitosan Oligosaccharide is highly soluble in water, typically at a 1% solubility ratio, maximum 10%-20%,  ensuring rapid dissolution and easy integration into various formulations, particularly where quick absorption and bioactivity are required.

Kindly watch the videos of solubility of different types of vegetal chitosan: https://www.chibiotech.com/video/

Specification Customized Service
We provide tailored solutions to adjust the molecular weight, degree of deacetylation, and other specifications to meet your specific application needs, ensuring optimal performance and efficiency.

Advantages & Benefits

• Enhanced Bioavailability: Low molecular weight allows for rapid absorption and high bioactivity in various biological applications.
• Vegan and Non-Allergenic: Ideal for individuals with shellfish allergies or those following a vegan lifestyle.
• High Purity: Guarantees a clean, consistent product free from animal derivatives.
• Eco-Friendly: Produced sustainably, minimizing environmental impact.

Functions

• Immune Boosting: Supports immune function, making it ideal for dietary supplements and health products.
• Antimicrobial Properties: Inhibits bacterial and fungal growth, enhancing product safety and longevity.
• Biodegradability: Environmentally friendly, breaking down naturally without causing harm to ecosystems.
• Plant Growth Stimulant: Promotes plant growth and resilience, making it useful in agriculture.

Main Applications （More about applications)

• Dietary Supplements: Used for its health benefits, particularly in products aimed at immune support and gut health.
• Agriculture: Acts as a bio-stimulant, promoting plant growth and disease resistance.
• Cosmetics: Enhances skin care products with its moisturizing and bioactive properties.
• Food & Beverage: Serves as a natural preservative and functional ingredient in health-focused products.
• Nasal Spray: Utilized in nasal sprays for its biocompatibility and ability to enhance drug delivery through mucous membranes.

Flowchart
The production process of Aspergillus Niger Chitosan Oligosaccharide involves dissolving chitosan in acetic acid, followed by enzymatic hydrolysis to reduce molecular weight, and then undergoing filtration, drying, sieving, and final testing to ensure the highest quality.

The flowchart of aspergillus niger chitosan outlines the process for extracting chitosan from Aspergillus niger, a type of fungus. Here’s a step-by-step summary of the key points:

1. Starting Material: Aspergillus niger is cultured through a fermentation process using corn.
2. Extraction:
   • The fungal biomass undergoes a bulk flocculation.
   • This is followed by centrifugation to separate the components.
   • The pH of the resulting material is adjusted to alkaline conditions (pH 8-10).
   • Another round of centrifugation and isolation occurs.
   • The pH is adjusted back to neutral (pH 7), and the sediment is washed and precipitated.
   • The sediment is then extracted with 5% acetic acid at 100°C for five hours to get the clear solution.
   • It is washed again to achieve a clear solution with a neutral pH.
3. Chitin Production:
   • The clear solution is treated with 7% sodium hydroxide (NaOH) at a ratio of 1:10 (W/V) at 50°C for three hours.
   • Centrifugal washing follows, resulting in the production of chitin as a clear solution to get the sediment.
4. Deacetylation:
   • The sediment undergoes the deacetylation process. It’s treated with 20% NaOH at a ratio of 1:10 (W/V) and heated in a microwave at 480W for 15 minutes.
   • This step is crucial to convert chitin into chitosan by removing acetyl groups.
5. Final Steps:
   • The final sediment, which is now deacetylated chitin or chitosan, is extracted.
   • It undergoes drying, followed by sieving to achieve the desired particle size.
6. End Product: The final product is solid Aspergillus niger chitosan.

This process includes several steps involving pH adjustment, centrifugation, chemical treatments, and heating, which are critical to ensuring the purity and quality of the chitosan extracted from Aspergillus niger.

Here are simplified descriptions of the flowcharts for Chitosan Oligosaccharide:

Chitosan Oligosaccharide Production:

• Step 1: Chitosan is dissolved in acetic acid to form a solution.
• Step 2: Enzymatic hydrolysis is applied, followed by degradation.
• Step 3: The solution undergoes filtration and precipitation.
• Step 4: The product is dried, sieved, and tested.
• Result: Chitosan Oligosaccharide.

 

Why Choose Us? (>>See more about us)

• Expertise: With over 8 years of experience, Chibio Biotech is a trusted leader in producing high-quality fungal-derived chitosan and oligosaccharides.
• Certified Quality: Our products are ISO 22000:2018, Halal, Kosher, and Organic certified, ensuring compliance with the highest industry standards.  (>>See more about our certificates)
• Customized Solutions: We offer bespoke chitosan solutions tailored to your specific needs, ensuring optimal performance.
• Global Reach: Serving customers in over 50 countries, we have the expertise and capacity to support your business worldwide.

Why your businesses consider using vegetal chitosan?

Using vegetal chitosan in your applications or formulations offers significant benefits to businesses, as outlined below:

1. Eco-Friendly and Sustainable: Vegetal chitosan is derived from plant sources such as mushrooms and fungi, making it an environmentally sustainable alternative to traditional animal-based chitosan. This aligns with growing consumer demand for green and eco-friendly products​​.
2. Non-Allergenic and Vegan-Friendly: Unlike crustacean-derived chitosan, vegetal chitosan does not trigger shellfish allergies and is suitable for vegan and vegetarian consumers. This widens the market reach for products formulated with vegetal chitosan​.
3. Versatility and Superior Functionality: Vegetal chitosan offers excellent biocompatibility, biodegradability, and antimicrobial properties. These attributes enhance its utility across various industries, including food, pharmaceuticals, cosmetics, textiles, and agriculture​​​.
4. Enhanced Product Performance: In many applications, vegetal chitosan improves product qualities such as moisture retention, antimicrobial efficacy, and barrier properties. This leads to better-performing end products, such as longer shelf-life for food items or improved durability and functionality in textiles​​.
5. Market Differentiation: Incorporating vegetal chitosan allows companies to differentiate their products by promoting natural, sustainable, and allergen-free claims, which are increasingly valued by health-conscious and environmentally aware consumers​​.

In summary, using vegetal chitosan can help your businesses enhance their product offerings, meet consumer demands for sustainable and non-allergenic ingredients, and improve your overall market positioning.

 

Explore the benefits of Water-soluble Aspergillus Niger Chitosan Oligosaccharide today! Contact us for more details or to request COA and a custom quote.