Agaricus Bisporus Carboxymethyl Chitosan

Agaricus Bisporus Carboxymethyl Chitosan

Additional information

Product Name

Agaricus Bisporus Carboxymethyl Chitosan

Form

Off-white to white powder

Source

Agaricus Bisporus (White Button Mushroom)

Cas No.

83512-85-0

Specification

N,O-CMC, Substitution degree: NLT 90%

Main Applictions

Pharmaceuticals, Wound Healing, Cosmetics, Tissue Regeneration etc.

Product Details

Agaricus Bisporus Carboxymethyl Chitosan (N,O Substituted) – Advanced Mushroom-Derived Chitosan

What is Agaricus Bisporus Carboxymethyl Chitosan (N,O Substituted) (N,O-CMC)?
Agaricus Bisporus Carboxymethyl Chitosan (N,O Substituted) (N,O-CMC)is a highly specialized derivative of chitosan, sourced from Agaricus bisporus (white button mushroom).

This chitosan has been chemically modified by carboxymethylation at both the amino (N) and hydroxyl (O) groups, significantly enhancing its solubility and expanding its functional properties.

It is an ideal ingredient for advanced applications in pharmaceuticals, wound care, tissue regeneration, and cosmetics.

CAS Number:

  • CAS No.: 83512-85-0

Chemical Structure:

  • Chemical Formula: (C8H15NO7)n(C_8H_{15}NO_7)_n
  • The chemical structure of dual substituted carboxymethyl chitosan includes both amino (–NH_2) and hydroxyl (–OH) groups that are substituted with carboxymethyl groups (–CH_2COOH). This dual substitution increases the polymer’s solubility and enhances its functional properties, such as biocompatibility and bioactivity.

The repeating unit can be represented as:

  • [–(C_6H_{9}O_4)–NH–CH_2–COOH–]n + [–C_6H_{9}O_4–O–CH_2–COOH–]n

Where:

  • NH represents the amino group substitution, and O represents the hydroxyl group substitution with carboxymethyl groups.
  • “n” represents the degree of polymerization, which can vary based on specific applications.

Specification

  • Appearance: Off-white to light yellow powder
  • Degree of Substitution (DS): Typically not less than 90%
  • Viscosity: 10-80cps (typically around 60cps, maximum 100-200cps)
  • Molecular Weight: Varies depending on application requirements
  • Solubility: Highly soluble in water

This table illustrates a direct correlation between the viscosity and molecular weight of chitosan, where higher molecular weights result in increased viscosity.

This relationship is crucial for selecting the appropriate chitosan grade for various applications, as higher viscosity chitosan, due to its larger molecular structure, is ideal for creating thicker gels and films.

Solubility

This N,O substituted agaricus bisporus chitosan is fully soluble in water, with ration 1% (1g chitosan dissolved in 99ml water), even at neutral pH, making it versatile for a wide range of applications, especially where enhanced solubility and bioactivity are critical.

Kindly watch the videos of solubility of different types of vegetal chitosan: https://www.chibiotech.com/video/

Specification Customized Service

We offer customized solutions to adjust the degree of substitution, molecular weight, and other properties to meet your specific application requirements, ensuring optimal performance.

Advantages & Benefits

  • Enhanced Solubility: Dual substitution ensures complete solubility in water, ideal for diverse applications.
  • Vegan and Non-Allergenic: Sourced from mushrooms, making it suitable for vegans and individuals with shellfish allergies.
  • High Biocompatibility: Safe for use in medical, pharmaceutical, and cosmetic applications with minimal risk of adverse reactions.
  • Eco-Friendly: Produced sustainably, contributing to environmental preservation.

Functions

  • Wound Healing: Promotes faster and more effective wound healing due to its biocompatibility and antimicrobial properties.
  • Tissue Regeneration: Supports tissue regeneration and repair, making it valuable in biomedical applications.
  • Moisturizing Agent: Excellent for retaining moisture, making it ideal for skincare and cosmetic formulations.
  • Biodegradability: Environmentally friendly, naturally decomposing without harming ecosystems.

Main Applications (More about applications)

  • Pharmaceuticals: Used in drug delivery systems, wound care products, and as a stabilizing agent.
  • Cosmetics: Enhances moisturization, provides skin protection, and improves the texture of lotions, creams, and gels.
  • Wound Healing: Accelerates wound healing and tissue regeneration, making it essential for advanced wound care products.
  • Tissue Regeneration: Ideal for use in tissue engineering and regenerative medicine due to its supportive properties.

Flowchart
The production process of Agaricus Bisporus Carboxymethyl Chitosan (N,O Substituted) involves careful chemical modification of chitosan with carboxymethyl groups at both the N and O positions, followed by purification, drying, and rigorous quality testing. The flowchart of mushroom (oyster mushroom or agaricus bisporus) chitosan illustrates the process of producing chitosan and its derivatives from mushroom material. Here’s a summary of the key content:

  1. Starting Material: The process begins with mushroom material as the source.
  2. Filtration: The mushroom material undergoes a filtration process.
  3. Protein Removal: Proteins are then removed from the filtered material using an alkali solution.
  4. Ash Removal: Ash content is subsequently removed with acid.
  5. Chitin Extraction:
    • Acid is added without bubbles to proceed to the next stage.
    • Chitin is extracted, which is not soluble in acid.
    • An acetylation step removes the acetyl groups from the chitin using sodium hydroxide (NaOH), converting it into chitosan, which is soluble in acid.
  6. Drying: The acid-soluble chitosan is then dried to produce the final mushroom chitosan product, showcased as a white powder.
  7. Chitosan Derivatives: Parallel to the drying process, there is a branch leading to the production of various chitosan derivatives:
    • Chitosan Hydrochloride: Chitosan converted into its hydrochloride form.
    • Enzyme Hydrolysis: Produces chitosan oligosaccharide through enzymatic hydrolysis.
    • Carboxymethyl Chitosan: Derived through the carboxymethylation of chitosan.

The flowchart depicts a methodical approach to converting mushroom material into various forms of chitosan, focusing on the purification and chemical modification steps necessary to achieve different chitosan-based products for use in various applications.

Here is a simplified description of the flowchart for Agaricus Bisporus Carboxymethyl Chitosan production:

  1. Start with Mushroom Chitosan: The process begins with the preparation of mushroom-derived chitosan.
  2. Alkaline Solution Preparation: Add NaOH to create an alkaline solution.
  3. Carboxymethylation: Add chloroacetic acid to introduce carboxymethyl groups into the chitosan.
  4. pH Adjustment: Adjust the pH by adding HCl.
  5. Ethanol Addition: Add natural ethanol to the solution.
  6. Washing and Centrifugation: The product undergoes washing, followed by centrifugal separation.
  7. Drying and Sieving: The product is then dried and sieved.
  8. Final Testing: The final product, Agaricus Bisporus Carboxymethyl Chitosan, is tested for quality assurance.

Why Choose Us?(>>See more about us)

  • Expertise: With over 8 years of experience, Chibio Biotech is a leading provider of high-quality mushroom-derived chitosan, including advanced derivatives like N,O substituted carboxymethyl chitosan.
  • Certified Quality: Our products are ISO 22000:2018, Halal, Kosher, and Organic certified, ensuring adherence to the highest industry standards.  (>>See more about our certificates)
  • Customized Solutions: We offer bespoke chitosan solutions tailored to your specific needs, ensuring the best performance for your applications.
  • Global Reach: Serving customers in over 50 countries, we have the expertise and capacity to support your business wherever you are.

 

Why your businesses consider using vegetal chitosan?

Using vegetal chitosan in your applications or formulations offers significant benefits to businesses, as outlined below:

  1. Eco-Friendly and Sustainable: Vegetal chitosan is derived from plant sources such as mushrooms and fungi, making it an environmentally sustainable alternative to traditional animal-based chitosan. This aligns with growing consumer demand for green and eco-friendly products​​.
  2. Non-Allergenic and Vegan-Friendly: Unlike crustacean-derived chitosan, vegetal chitosan does not trigger shellfish allergies and is suitable for vegan and vegetarian consumers. This widens the market reach for products formulated with vegetal chitosan​.
  3. Versatility and Superior Functionality: Vegetal chitosan offers excellent biocompatibility, biodegradability, and antimicrobial properties. These attributes enhance its utility across various industries, including food, pharmaceuticals, cosmetics, textiles, and agriculture​​​.
  4. Enhanced Product Performance: In many applications, vegetal chitosan improves product qualities such as moisture retention, antimicrobial efficacy, and barrier properties. This leads to better-performing end products, such as longer shelf-life for food items or improved durability and functionality in textiles​​.
  5. Market Differentiation: Incorporating vegetal chitosan allows companies to differentiate their products by promoting natural, sustainable, and allergen-free claims, which are increasingly valued by health-conscious and environmentally aware consumers​​.

In summary, using vegetal chitosan can help your businesses enhance their product offerings, meet consumer demands for sustainable and non-allergenic ingredients, and improve your overall market positioning.

 

Explore the benefits of Agaricus Bisporus Carboxymethyl Chitosan (N,O Substituted) today! Contact us for more details or to request a custom quote.

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